Based on the theory of modern separation science, chromatography is by far one of the most efficient methods that can achieve millions of plate number. In theory using high performance liquid chromatography(HPLC) to conduct scale separation and purification is totally feasible. 

Comparing with traditional separation and purification method, 5 advantages of Chromatography are:

(1) Wide application range   

It applies to all compounds no matter it is polar or non-polar, ionic or non-ionic, micro or macro molecular, organic or inorganic, or biologically active substance, or thermally stable or unstable. Chromatography is especially irreplaceable in the separation and preparation of biological macro molecules.

(2) High efficiency  

In terms of chromatography column efficiency, its theory plate number ranges from several thousands to several ten thousands, especially applicable to the separation of complex mixtures with requirement of high yield and high level of purification.

(3) Multiple options  

Chromatography allows different separation methods to meet different sample requirement, such as adsorption, partition, affinity etc., There are also choices for different status and types of solid and liquid phase and choices of batch chromatography and continuous chromatography.

(4) Scale production  

Industrial production can be achieved based on further study of stable laboratory production with full consideration of all processes amplified in industrial environment.

(5) Synchronized monitoring  

Highly sensitive detectors can continuously monitor the separation and purification process in synchronization for different products by applying  different physical and chemical principles. 

People have developed many methods to use liquid chromatography to separate compounds and the choice of methods lies in the physicochemical characteristics of the molecule to be separated. The solid phases used for chromatography, also called chromatography media, are porous inert supports and can be functionalized with various chemical groups to dictate the interactions with the molecules to be separated. 

In applicaiton, sensible choice of right solid phase or packing material is the core of Chromatography, for it plays a significant role in the results and efficiency of extraction and purification process. Qingdao Bangkai Hi-tech Materials Co.,Ltd is specialized in the research and manufacturing of chromatography related materials and equipments with an individual R&D center. Based on their research and production practice, Silica gel is one of the most versatile and effective packing material in chromatography and is also one of the most popularly and widely used in fields like modern biomedicine, life science, fine chemistry, analytical chemistry, organic chemistry, biochemistry, food safety, plant extraction, scientific analysis, environement mornitoring, petrochemicals etc.,

Silica gel is a polar absorbent with slight acidity. It absorbs components in a mixture and can meanwhile remain neutral and maintain its own structure in the due process. Silica based packing material also features high mechanical strength and can endure high pressure and speed.   Silica-based packing material produced by Qingdao Bangkai is newly developed by its R&D centre and is with higher purity and lower metal content, and bonded with multiple functional groups, and has higher reproducibility and load capacity. One of Bangkai’s newly developed silica-based packing material has been sucessufly validated to be used in electro-optical products. It can be customized upon request and is the ideal choice for the improvement of separation&purification process and repalcement of similiar products in the international market.